Synthesis and Functionalisation of Superparamagnetic Nano-Rods towards the Treatment of Glioblastoma Brain Tumours

The complete removal of glioblastoma brain tumours is impossible to achieve by surgery alone due the complex finger-like tentacle structure tumour cells and their migration away from bulk at time surgery; furthermore, despite aggressive chemotherapy radiotherapy treatments following surgery, continue grow, leading death patients within 15 months after diagnosis. naturally occurring carnosine dipeptide has previously demonstrated activity against in vitro cultured cells; however, natural physiological concentrations, its too low have a significant effect. Towards realising full oncological potential carnosine, was embedded an externally triggered carrier, comprising novel nano rod-shaped superparamagnetic iron oxide nanoparticle (ca. 86 × 19 11 nm) capped with branched polyethyleneimine, which released therapeutic agent presence external magnetic field. new nano-carrier characterized using electron microscopy, dynamic light scattering, elemental analysis, resonance imaging techniques. In addition cytotoxicity studies, carrier’s effectiveness as treatment for screened U87 human astrocytoma cell line. labile (100 mM) suppresses both cells’ proliferation mobility over 48 h, resulting reduction metastasis. Carnosine found be fully carrier only mild hyperthermia conditions (40 °C), facilitating achievable clinical application slow, sustained-release that demonstrates inhibit post-surgery metastasis added benefit non-invasive monitoring via MRI.